Three New (Possible) Fibromyalgia Drugs

Donna Burch, over at Fed Up With Fatigue, wrote THIS article for the National Pain Report last week which details the three new fibromyalgia drugs in the pipeline.


Here is my  summary and take on these potential options:

1.  IMC-1 Combination – this combo drug works under the assumption that fibromyalgia is actually a latent HSV-1 virus. It is comprised of an antiviral (famvir) and Celebrex. I took Celebrex for severe menstrual pain back in 2005/2006 and it was great, but then I was told it increased your risk for heart disease, so I stopped using it. Perhaps others with more severe, can-barely-move type of pain, would take this risk, but I am not willing to put my heart in jeopardy for less pain at this point. And if I am being honest, I don’t think fibromyalgia is latent HSV-1.

2.  Mirogabalin – may relieve pain by binding to calcium channels. Studies showing the concept works as a potential treatment for diabetic peripheral neuropathic pain (DPNP), leads researchers to believe that it may also work in other chronic pain conditions, including fibromyalgia.

3.  Tonmya – this is basically a sublingual form of Flexeril. Flexeril is often prescribed for fibromyalgia as a muscle relaxant and sleep aid. Sublingual doses would offer a quicker relief time and customized low dosing. Tonmya assumes fibromyalgia is essentially a sleep disorder and that by getting restorative sleep, pain will be minimized. Flexeril has been suggested to me multiple times, but I have passed on it due to its habit-forming nature. I imagine the abuse potential would be much greater for a sublingual form, so I’m sure that will influence it’s availability.

So pretty much, none of these get me excited.


What does excite me a little, is Low Dose Naltrexone (LDN). I have been seeing more and more fibro friends on social media using it with great results. Naltrexone is a FDA approved medication which helps heroin/opiate addicts by blocking opioid receptors. When taken in low doses, it somehow boosts the immune system and can help with a wide variety of issues including autoimmune disorders, central nervous system disorders, HIV and even cancer. Unfortunately, very few doctors are on board yet and I am not willing to have an online consultation to try it out…it feels so shady! But, from what I am seeing in some groups, more and more neurologists, internists and even rheumatologists, are considering it as part of a treatment plan for their fibro patients.

Have a great weekend!



2 thoughts on “Three New (Possible) Fibromyalgia Drugs

  1. Very interesting! I totally agree with your take, that low-dose naltrexone seems to hold the most promise. I had to take a pharmacology class as one of my PT prerequisites. We learned a little bit about naltrexone– it’s a very interesting drug. I’ll be keeping my eye out for more on its uses for pain in the future!

    Liked by 1 person

  2. Great post! Though I have found reasonable relief from the pain and other symptoms with lyrica, I know it doesn’t do much for others. There definitely needs to be more options for fibromyalgia patients. Unfortunately, since the etymology is not really know, it is hard to devise potent drugs. Currently they all only address symptoms in lieu of any knowledge of its main origin.


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