Here is my summary and take on these potential options:
1. IMC-1 Combination – this combo drug works under the assumption that fibromyalgia is actually a latent HSV-1 virus. It is comprised of an antiviral (famvir) and Celebrex. I took Celebrex for severe menstrual pain back in 2005/2006 and it was great, but then I was told it increased your risk for heart disease, so I stopped using it. Perhaps others with more severe, can-barely-move type of pain, would take this risk, but I am not willing to put my heart in jeopardy for less pain at this point. And if I am being honest, I don’t think fibromyalgia is latent HSV-1.
2. Mirogabalin – may relieve pain by binding to calcium channels. Studies showing the concept works as a potential treatment for diabetic peripheral neuropathic pain (DPNP), leads researchers to believe that it may also work in other chronic pain conditions, including fibromyalgia.
3. Tonmya – this is basically a sublingual form of Flexeril. Flexeril is often prescribed for fibromyalgia as a muscle relaxant and sleep aid. Sublingual doses would offer a quicker relief time and customized low dosing. Tonmya assumes fibromyalgia is essentially a sleep disorder and that by getting restorative sleep, pain will be minimized. Flexeril has been suggested to me multiple times, but I have passed on it due to its habit-forming nature. I imagine the abuse potential would be much greater for a sublingual form, so I’m sure that will influence it’s availability.
So pretty much, none of these get me excited.
What does excite me a little, is Low Dose Naltrexone (LDN). I have been seeing more and more fibro friends on social media using it with great results. Naltrexone is a FDA approved medication which helps heroin/opiate addicts by blocking opioid receptors. When taken in low doses, it somehow boosts the immune system and can help with a wide variety of issues including autoimmune disorders, central nervous system disorders, HIV and even cancer. Unfortunately, very few doctors are on board yet and I am not willing to have an online consultation to try it out…it feels so shady! But, from what I am seeing in some groups, more and more neurologists, internists and even rheumatologists, are considering it as part of a treatment plan for their fibro patients.
Have a great weekend!